Mt. 10:39 reads "He that would save his life will lose it. He that loses his life for my sake shall find it."
The importance of this scripture is reflected in that it is used six times in the New Testament! It's helpful to look at the word "life". There are three words for life in the New Testament. In Greek they are pseuche, bios, and zoe. Pseuche is used to denote breath, the life that we are born into. Bios is our way of life like our jobs. Zoe is the life of God that comes into us us when we receive Jesus into our heart and confess Him as Lord of our lives.So with this understanding, when the scripture says that "he that would save his life,(( and here it uses the word "pseuche"), will lose it. It is saying that for the person to hang on, to preserve, to not move from the sin stained birthed life, will lose it. This would end in death and condemnation to Hell. But for the person that "loses" that life by dying to sin and believing in and receiving Jesus (for my sake) as Lord and Savior, he will "find" an abundant and eternal life that never ends. The first Adam was a "living soul" or pseuche; the second Adam (Jesus) was a "life" (zoe) giving spirit.(1 Cor 15:45). "He that hath the Son hath life (zoe); he that hath not the Son hath not life (1 Jo. 5:12). So, the scriptural exhortation is,"receive the Son.Get a life (zoe)!
And we need to continue upon receiving this God life (zoe) to press toward the goal for the prize of the upward call of God in Christ. That means not longing for the old, like Lot's wife, good ol' days of the sin infested life that we have been freed from. It means not sowing to the flesh which brings corruption but rather sowing to the spirit which reaps eternal life.
It means not saving the old life and therefore "losing out" but rather losing that life (pseuche) and finding that wonderful abundant spirit empowering life of Christ.
Remember the words of the martyred missionary, Jim Elliot, when he wrote, "He is no fool who gives what he cannot keep to gain that which he cannot lose."